Visual Detection of Copper(II) by Azide‐ and Alkyne‐Functionalized Gold Nanoparticles Using Click Chemistry

作者：Yang Min Zhou, Shixing Wang, Ke Zhang, Xingyu Jiang · 发表于：Angewandte Chemie International Edition · 年份：2008 · DOI：10.1002/anie.200802317 · 被引用次数：452 · 研究领域：Click Chemistry and Applications、Advanced biosensing and bioanalysis techniques、Advanced Biosensing Techniques and Applications

Just one click, and the color's gone: In the presence of Cu2+ with sodium ascorbate as a reductant, gold nanoparticles that have azide- and alkyne-terminated groups undergo aggregation as the result of CuI-catalyzed click chemistry. This process can be monitored by eye without the aid of instruments (NPs=nanoparticles).