Genome of the Chinese tree shrew

作者：Yu Fan, Zhiyong Huang, Changchang Cao, Ceshi Chen, Yuan-Xin Chen, Dingding Fan, Jing He, Haolong Hou, Long-Long Hu, Xintian Hu, Xuanting Jiang, Ren Lai, Yongshan Lang, Bin Liang, Sheng-Guang Liao, Dan Mu, Yuanye Ma, Yuyu Niu, Xiaoqing Sun, Jinquan Xia, Jin Xiao, Zhiqiang Xiong, Lin Xu, Lan Yang, Yun Zhang, Wei Zhao, Xudong Zhao, Yong‐Tang Zheng, Jumin Zhou, Yabing Zhu, Guojie Zhang, Jun Wang, Yong‐Gang Yao · 发表于：Nature Communications · 年份：2013 · DOI：10.1038/ncomms2416 · 被引用次数：379 · 研究领域：Cancer-related molecular mechanisms research、Bat Biology and Ecology Studies、interferon and immune responses

Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as models for a variety of human disorders: depression, myopia, hepatitis B and C virus infections, and hepatocellular carcinoma, to name a few. Here we present a publicly available annotated genome sequence for the Chinese tree shrew. Phylogenomic analysis of the tree shrew and other mammalians highly support its close affinity to primates. By characterizing key factors and signalling pathways in nervous and immune systems, we demonstrate that tree shrews possess both shared common and unique features, and provide a genetic basis for the use of this animal as a potential model for biomedical research. The Chinese tree shrew, Tupaia belangeri chinensis, has been proposed as a potential animal model in biomedical research and drug safety testing. This study presents the full genome of the Chinese tree shrew, identifying common features between the tree shrew and primates.