Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

作者：Australian Cancer Study, Stig E. Bojesen, Australian Ovarian Cancer Study, Gene Environment Interaction and Breast Cancer (GENICA), Swedish Breast Cancer Study (SWE-BRCA), Epidemiological study of BRCA1 & BRCA2 Mutation Carriers (EMBRACE), Genetic Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers (GEMO), Karen A. Pooley, Sharon E. Johnatty, Jonathan Beesley, Kyriaki Michailidou, Jonathan P. Tyrer, Stacey L. Edwards, Hilda A. Pickett, Howard C. Shen, Chanel Elisha Smart, Kristine M. Hillman, Phuong L. Mai, Kate Lawrenson, Michael D. Stutz, Yi Lu, Rod Karevan, Nicholas T. Woods, Rebecca L. Johnston, Juliet D. French, Xiaoqing Chen, Maren Weischer, Sune Fallgaard Nielsen, Mel J. Maranian, Maya Ghoussaini, Shahana Ahmed, Caroline Baynes, Manjeet K. Bolla, Qin Wang, Joe Dennis, Lesley McGuffog, Daniel Barrowdale, Andrew S. Lee, Sue C. Healey, Michael J. Lush, Daniel C. Tessier, Daniel Vincent, François Bacot, Ignace B. Vergote, Sandrina Lambrechts, Evelyn Despierre, Harvey A. Risch, Anna González‐Neira, Mary Anne Rossing, Guillermo Pita, Jennifer A. Doherty, Núria Álvarez, Melissa C. Larson, Brooke L. Fridley, Nils Schoof, Jenny C. Chang-Claude, Mine S. Cicek, Julian Peto, Kimberly R. Kalli, Annegien Broeks, Sebastian M. Armasu, Marjanka K. Schmidt, Linde M. Braaf, Boris J. N. Winterhoff, Heli A. Nevanlinna, Gottfried E. Konecny, Diether Lambrechts, Lisa Rogmann, Pascal Guénel, Attila Teoman, Roger Laughlin Milne, Joaquín J. García, Angela Cox, Vijayalakshmi Shridhar, Barbara Burwinkel, Frederik Marmé, Rebecca Hein, Elinor J. Sawyer, Christopher A. Haiman, Shan Wang‐Gohrke, Irene Louise Andrulis, Kirsten B. Moysich, John L. Hopper, Kunle O. Odunsi, Annika Lindblom, Graham G. Giles, Hermann Brenner, Jacques Simard, Galina Lurie, Peter Andreas Fasching, Michael E. Carney, Paolo Radice, Lynne Ross Wilkens, Anthony J. Swerdlow, Marc T. Goodman, Hiltrud B. Brauch, Montserrat García‐Closas, Peter Hillemanns, Robert Winqvist, Matthias Dürst, Peter Devilee, Ingo B. Runnebaum, Anna Jakubowska, Jan Lubiński, Arto Mannermaa, Ralf C. Bützow, Natalia Bogdanova, Thilo Dörk, Liisa M. Pelttari, Wei Zheng, Arto Leminen, Hoda Anton‐Culver, Clareann H. Bunker, Vessela Nedelcheva Kristensen, Roberta B. Ness, Kenneth Ross Muir, Robert P. Edwards, Alfons Meindl, Florian Heitz, Keitaro Matsuo, Andreas du Bois, Anna H. Wu, Philipp Harter, Soo‐Hwang Teo, Ira Schwaab, Xiao‐Ou Shu, William J. Blot, Satoyo Hosono, Daehee Kang, Toru Nakanishi, Mikael Hartman, Yasushi Yatabe, Ute Hamann, Beth Y. Karlan, Suleeporn Sangrajrang, Susanne K. Kjær, Valérie Gaborieau, Allan Jensen, Diana Eccles, Estrid Vilma Solyom Høgdall, Chen‐Yang Shen, Judith D. Brown, Yin Ling Woo, Mitul Shah, Mat Adenan Noor Azmi, Robert Luben, Siti Zawiah Omar, Kamila Czene, Robert Alan Vierkant, Børge Grønne Nordestgaard, Henrik Flyger, Celine M. Vachon, Janet E. Olson, Xianshu Wang, Douglas A. Levine, Anja Rudolph, Rachel Palmieri Weber, Dieter Flesch‐Janys, Edwin S. Iversen, Stefan Nickels, Joellen M. Schildkraut, Isabel dos‐Santos‐Silva, Daniel William Cramer, Lorna J. Gibson, Kathryn L. Terry, Olivia Fletcher, Allison F. Vitonis, C. Ellen van der Schoot, Elizabeth M. Poole, Frans B.L. Hogervorst, Shelley S. Tworoger, Jianjun Liu, Elisa Victoria Bandera, Jingmei Li, Sara H. Olson, Keith Humphreys, Irene Orlow, CARL P. BLOMQVIST, Lorna Rodríguez-Rodríguez, Kristiina Aittomäki, Helga Birgitte Salvesen, Taru Muranen, Elisabeth Wik, Barbara Anna Henk Brouwers, Camilla Krakstad, Els Wauters, Mari K. Halle, Hans P. M. W. Wildiers, Lambertus A.L.M. Kiemeney, Claire Mulot, Katja K.H. Aben, Pierre Laurent‐Puig, Anne M. van Altena, Thérèse Truong, Leon F.A.G. Massuger, Javier Benı́tez, Tanja B. Pejovic, José Ignacio Arias Pérez, Maureen E. Hoatlin, M. Pilar Zamora, Linda S. Cook, Sabapathy P. Balasubramanian, Linda E. Kelemen, Andreas Schneeweiß, Nhu D. Le, Christof Sohn, Angela R Brooks-Wilson, Ian P.M. Tomlinson, Michael J. Kerin, Nicola Miller, Cezary Cybulski, Brian E. Henderson, Janusz Menkiszak, Fredrick R. Schumacher, Nicolas Wentzensen, Loı̈c Le Marchand, Hannah Yang, Anna Marie Mulligan, Gord Glendon, Svend Aage Engelholm, Julia A. Knight, Claus Kim Høgdall, Carmel Apicella, Martin Eric Gore, Helen Tsimiklis, Honglin Song, Melissa C. Southey, Agnes Jager, Ans M. W. den Van Ouweland, Robert Eldon Brown, John W.M. Martens, James M. Flanagan, Mieke Kriege, James Paul, Sara Margolin, Nadeem Siddiqui, Gianluca Severi, Alice S. Whittemore, Laura Baglietto, Valerie McGuire, Christa Stegmaier, Weiva Sieh, Heiko Müller, Volker Arndt, France Labrèche, Yu-Tang Gao, Mark S. Goldberg, Gong Yang, Martine Dumont, McLaughlin, Arndt Hartmann, Arif Bülent Ekici, Matthias W. Beckmann, Catherine M. Phelan, Michael Patrick Lux, Jenny Permuth‐Wey, Bernard Peissel, Thomas A. Sellers, Filomena Ficarazzi, Monica Barile, Argyrios Ziogas, Alan Ashworth, Aleksandra Gentry‐Maharaj, Michael Emlyn Jones, Susan J. Ramus, Nick Orr, Usha Menon, Celeste Leigh Pearce, Thomas Brüning, Malcolm C. Pike, Yon‐Dschun Ko, Jolanta Lissowska, Jonine D. Figueroa, Jolanta Kupryjańczyk, Stephen Jacob Chanock, Agnieszka Dansonka‐Mieszkowska, Arja Jukkola‐Vuorinen, Iwona K. Rzepecka, Katri Pylkäs, Mariusz Bidziński, Saila Kauppila, Antoinette Hollestelle, Caroline Seynaeve, Rob A.�E.�M. Tollenaar, Katarzyna Durda, Katarzyna Jaworska, Jaana M. Hartikainen, Veli-Matti Kosma, Vesa V Kataja, Natalia Antonenkova, Jirong Long, Martha J. Shrubsole, Sandra L. Deming-Halverson, Artitaya Lophatananon, Pornthep Siriwanarangsan, Sarah L. Stewart-Brown, Nina Ditsch, Peter Lichtner, Rita Katharina Schmutzler, Hidemi M. Ito, Hiroji Iwata, Kazuo Tajima, Chiu-Chen Tseng, Daniel O. Stram, David Van Den Berg, Cheng Har Yip, M. Kamran Ikram, Yew-Ching Teh, Hui Cai, Wei Lu, Lisa B. Signorello, Qiuyin Cai, Dong‐Young Noh, Keun-Young Yoo, Hui Miao, Philip Choong Tsau Iau, Yik Ying Teo, James McKay, Charles L. Shapiro, Foluso Olabisi Ademuyiwa, George Fountzilas, Chia-Ni Hsiung, Jyh-Cherng Yu, Ming‐Feng Hou, Catherine S. Healey, Craig Luccarini, Susan Peock, Dominique Stoppa‐Lyonnet, Paolo Peterlongo, Timothy R. Rebbeck, MARION R. PIEDMONTE, Christian Fridolin Singer, Eitan Friedman, Mads Thomassen, Kenneth Offit, Thomas van Overeem Hansen, Susan L. Neuhausen, Csilla I. Szabo, Ignacio Blanco, Judy Ellen Garber, Steven A. Narod, Jeffrey N. Weitzel, Marco Montagna, Edith Oláh, Andrew K. Godwin, Drakoulis Yannoukakos, David E. Goldgar, Trinidad Caldés, Evgeny N. Imyanitov, Laima Tihomirova, Banu Arun, Ian Campbell, Arjen R. Mensenkamp, Christi J. van Asperen, Kees E. P. van Roozendaal, Hanne E.J. Meijers-Heijboer, J. Margriet Collée, Jan C. Oosterwijk, Maartje J. Hooning, Matti A. Rookus, Rob B. van der Luijt, Theo A.M. van Os, D. Gareth Evans, Debra Frost, Elena Fineberg, Julian Barwell, Lisa Walker, Michael John Kennedy, Radka Platte, Rosemarie Davidson, Steve D. Ellis, Trevor R. P. Cole, Brigitte Bressac–de Paillerets, Bruno Buecher, Francesca Damiola, Laurence Faivre, Marc Frénay, Olga M. Sinilnikova, Olivier Caron, Sophie Giraud, Sylvie Mazoyer, Valérie Bonadona, Virginie Caux‐Moncoutier, Aleksandra Tołoczko‐Grabarek, Jacek Gronwald, Tomasz Byrski, Amanda B. Spurdle, Bernardo Bonanni, Daniela Zaffaroni, Giuseppe Giannini, Loris Bernard, Riccardo Dolcetti, Siranoush Manoukian, Norbert Arnold, Christoph Engel, Helmut Deißler, Kerstin Rhiem, Dieter Niederacher, Hansjoerg Plendl, Christian Sutter, Barbara Wappenschmidt, Åke Borg, Beatrice S. Melin, Johanna Rantala, Maria Soller, Katherine L. Nathanson, Susan M. Domchek, Gustavo C. Rodriguez, Ritu Salani, Daphne Gschwantler Kaulich, Muy-Kheng M. Tea, Shani Shimon Paluch, Yael Laitman, Anne‐Bine Skytte, Torben A. Kruse, Uffe Birk Jensen, Mark E. Robson, Anne‐Marie Gerdes, Bent Ejlertsen, Lenka Foretová, Sharon A. Savage, Jenny Lester, Penny Soucy, Karoline B. Kuchenbaecker, Curtis Olswold, Julie M. Cunningham, Susan Slager, V. Shane Pankratz, Ed Dicks, Sunil R. Lakhani, Fergus J. Couch, Per N Hall, Álvaro N.A. Monteiro, Simon A. Gayther, Paul D.P. Pharoah, Roger R. Reddel, Ellen L. Goode, Mark H. Greene, Douglas F. Easton, Andrew Berchuck, Antonis C. Antoniou, Georgia Chenevix‐Trench, Alison M. Dunning · 发表于：Nature Genetics · 年份：2013 · DOI：10.1038/ng.2566 · 被引用次数：544 · 研究领域：Telomeres, Telomerase, and Senescence、Cancer Research and Treatments、Genetics, Aging, and Longevity in Model Organisms