Zebrafish: A Complete Animal Model for In Vivo Drug Discovery and Development

作者：Chiranjib Chakraborty, Chi Chien Hsü, Zhi Hong Wen, Chang Lin, Govindasamy Agoramoorthy · 发表于：Current Drug Metabolism · 年份：2009 · DOI：10.2174/138920009787522197 · 被引用次数：280 · 研究领域：Zebrafish Biomedical Research Applications、CRISPR and Genetic Engineering、Pluripotent Stem Cells Research

In last few years, the use of zebrafish (Danio rerio) in scientific research is growing very rapidly. Initially, it was a popular as a model of vertebrate development because zebrafish embryos are transparent and also develop rapidly. Presently, the research using zebrafish is expanding into other areas such as pharmacology, clinical research as a diseases model and interestingly in drug discovery. The use of zebrafish in pharmaceutical research and discovery and drug development is mainly screening of lead compounds, target identification, target validation, morpholino oligonucleotide screens, assay development for drug discovery, physiology based drug discovery, quantitative structure-activity relationship (QSAR) and structure -activity relationships (SAR) study and drug toxicity study. In this paper, we have described properly all the areas of drug discovery where zebrafish is used as a tool. We are hopeful that the use of these techniques or methods will make the zebrafish a prominent model in drug discovery and development research in the forthcoming years.