Dynamic changes in water ADC, energy metabolism, extracellular space volume, and tortuosity in neonatal rat brain during global ischemia

作者：Annette van der Toorn, Eva Syková, Rick M. Dijkhuizen, Ivan Voříšek, Lýdia Vargová, Evan Škobisová, Menno van Lookeren Campagne, Torsten Reese, Klaas Nicolay · 发表于：Magnetic Resonance in Medicine · 年份：1996 · DOI：10.1002/mrm.1910360110 · 被引用次数：274 · 研究领域：Advanced MRI Techniques and Applications、NMR spectroscopy and applications、Advanced Neuroimaging Techniques and Applications

To obtain a better understanding of the mechanisms underlying early changes in the brain water apparent diffusion coefficient (ADC) observed in cerebral ischemia, dynamic changes in the ADC of water and in the energy status were measured at postnatal day 8 or 9 in neonatal rat brains after cardiac arrest using 1H MRS/MRI and 31P MRS, respectively. The time courses of the MR parameters were compared with changes in the extracellular space (ECS) volume fraction (alpha) and tortuosity (lambda), determined from concentration-time profiles of tetramethylammonium applied by iontophoresis. The data show a decrease of the ADC of tissue water after induction of global ischemia of which the time course strongly correlates with the time course of the decrease in the ECS volume fraction and the increase in ECS tortuosity. This indicates that cell swelling is an important cause for the ADC decrease of water.