Relationship between germination of Candida albicans and increased adherence to human buccal epithelial cells

作者：Lucille Kimura, Nancy N. Pearsall · 发表于：Infection and Immunity · 年份：1980 · DOI：10.1128/iai.28.2.464-468.1980 · 被引用次数：189 · 研究领域：Antifungal resistance and susceptibility、Probiotics and Fermented Foods、Fungal Infections and Studies

A strong correlation was shown between germination and increased adherence of Candida albicans to human buccal epithelial cells, indicating that germination or other changes in the fungi accompanying germination were responsible for enhanced adherence. Partial inhibition of germination by cysteine resulted in a comparably lower adherence. Preferential adherence of germinated fungi occurred in competition assays with nongerminated and germinated fungi. The enhanced adherence to human mucosal cells of germinated C albicans could represent one mechanism contributing to the pathogenicity of the organism.