Self-assembled Nano-layering at the Adhesive Interface

作者：Yasuhiro Yoshida, Kumiko Yoshihara, Noriyuki Nagaoka, Satoshi Hayakawa, Yuta TORII, T. Ogawa, Akiyoshi Osaka, Bart Van Meerbeek · 发表于：Journal of Dental Research · 年份：2012 · DOI：10.1177/0022034512437375 · 被引用次数：404 · 研究领域：Dental materials and restorations、Endodontics and Root Canal Treatments、Dental Implant Techniques and Outcomes

According to the 'Adhesion-Decalcification' concept, specific functional monomers within dental adhesives can ionically interact with hydroxyapatite (HAp). Such ionic bonding has been demonstrated for 10-methacryloyloxydecyl dihydrogen phosphate (MDP) to manifest in the form of self-assembled 'nano-layering'. However, it remained to be explored if such nano-layering also occurs on tooth tissue when commercial MDP-containing adhesives (Clearfil SE Bond, Kuraray; Scotchbond Universal, 3M ESPE) were applied following common clinical application protocols. We therefore characterized adhesive-dentin interfaces chemically, using x-ray diffraction (XRD) and energy-dispersive x-ray spectroscopy (EDS), and ultrastructurally, using (scanning) transmission electron microscopy (TEM/STEM). Both adhesives revealed nano-layering at the adhesive interface, not only within the hybrid layer but also, particularly for Clearfil SE Bond (Kuraray), extending into the adhesive layer. Since such self-assembled nano-layering of two 10-MDP molecules, joined by stable MDP-Ca salt formation, must make the adhesive interface more resistant to biodegradation, it may well explain the documented favorable clinical longevity of bonds produced by 10-MDP-based adhesives.