Dynamic Combinatorial Chemistry and Virtual Combinatorial Libraries

作者：Jean‐Maríe Lehn · 发表于：Chemistry - A European Journal · 年份：1999 · DOI：10.1002/(sici)1521-3765(19990903)5:9<2455::aid-chem2455>3.0.co;2-h · 被引用次数：891 · 研究领域：Catalysis and Oxidation Reactions、Computational Drug Discovery Methods

The reversible connection between sets of basic components allows the generation of a large collection of compounds constituted by all possible combinations that are potentially available. It makes virtual combinatorial libraries of substances accessible through a dynamic approach to combinatorial chemistry. The thermodynamically-driven evolution of the system leads to the actual expression of the constituent(s) that present(s) the best binding to/molecular recognition with the target site (see diagram). The general concept of this methodology has wide applications in a variety of areas of science and technology.