Heat-Inducible Human Factor That Binds to a Human hsp70 Promoter

作者：Robert E. Kingston, Thomas Schuetz, Zoia Larin · 发表于：Molecular and Cellular Biology · 年份：1987 · DOI：10.1128/mcb.7.4.1530-1534.1987 · 被引用次数：232 · 研究领域：Heat shock proteins research、Protein Structure and Dynamics、Endoplasmic Reticulum Stress and Disease

A factor found in nuclear extracts of human cells bound to the heat shock element of a human heat shock protein 70 gene. The level of this factor was significantly increased after heat shock. This induction was rapid and was not blocked by cycloheximide, suggesting that an initial event in the response of a human cell to heat is the activation of a preexisting regulatory factor.