oxyR-dependent induction of Escherichia coli grx gene expression by peroxide stress

作者：K Tao · 发表于：Journal of Bacteriology · 年份：1997 · DOI：10.1128/jb.179.18.5967-5970.1997 · 被引用次数：44 · 研究领域：Redox biology and oxidative stress、Bacterial Genetics and Biotechnology、Neutrophil, Myeloperoxidase and Oxidative Mechanisms

The Escherichia coli OxyR protein is a transcriptional activator for a number of genes induced in response to low concentrations of hydrogen peroxide. To identify additional OxyR-regulated genes, I cloned a DNA fragment that shows promoter activity regulated by OxyR by direct selection of OxyR-binding DNA fragments. Analyses of the cloned fragment indicate that the grx gene, encoding glutaredoxin 1, is inducible by hydrogen peroxide in an oxyR-dependent fashion.