Cellular Signaling Pathways and Cytoskeletal Organization

作者：Kenneth S. Kosik, Wei Qiao Qiu, Steven Mark Greenberg · 发表于：Annals of the New York Academy of Sciences · 年份：1996 · DOI：10.1111/j.1749-6632.1996.tb34409.x · 被引用次数：10 · 研究领域：Alzheimer's disease research and treatments、Wnt/β-catenin signaling in development and cancer、Cellular transport and secretion

We describe a possible mechanism by which the amyloid precursor protein (APP) may be linked to the intraneuronal pathology of Alzheimer's disease (AD). Extracellular proteolytic products of APP may directly or indirectly transduce signals to cells under normal as well as pathological conditions. This activity appears to reside in the cysteine-rich amino terminus of APP. How APP or its metabolic products may affect the phosphorylation of tau is considered.