Epithelial cell proliferation during organogenesis of rat colon

作者：Gregory L. Eastwood, Jerry S. Trier · 发表于：The Anatomical Record · 年份：1974 · DOI：10.1002/ar.1091790303 · 被引用次数：37 · 研究领域：Digestive system and related health、Helicobacter pylori-related gastroenterology studies、Infant Nutrition and Health

Abstract Between the 16th to the 20th day of gestation, the mucosa of the colon of fetal rats changes from a simple tube with a tiny lumen lined by stratified epithelium to a much more complex structure with a large lumen and well‐developed crypts lined by a single layer of columnar epithelium. Autoradiographic studies with 3H‐thymidine show that cell proliferation is present throughout the stratified epithelium but becomes confined to the lower half of colonic crypts immediately on their formation. The number of epithelial cells shown to be proliferating after exposure to a single pulse of 3H‐thymidine is high during this period of organogenesis but decreases rapidly after the 20th day of gestation once the adult mucosal pattern has formed.