The influence of age on the intestinal absorption of 47-Ca absorption in post-menopausal osteoporosis.

作者：Louis V. Avioli, Joseph E. McDonald, S W Lee · 发表于：Journal of Clinical Investigation · 年份：1965 · DOI：10.1172/jci105302 · 被引用次数：191 · 研究领域：Bone health and osteoporosis research

The literature is still controversial regarding the intestinal absorption of calcium in osteoporosis, with conflicting reports of decreased absorption (1-4), increased absorption (5-7), and normal absorption (8-10).The apparent discrepancies in these reports may stem from a) the absence of a common isotopic absorption test wherein oral "7Ca doses of uniform specific activity are adminis- tered in the fasting state, b) wide variations in the amount and chemical form of the administered stable calcium carrier, c) inadequate identification of the osteoporotic disease process and its differ- entiation from osteomalacia, d) the lack of suffi- cient age-matched nonosteoporotic controls for comparison, and e) wide variations in dietary cal- cium intakes, which prohibit adequate comparison between individual reports.The lack of reported investigations in humans relating the absorptive capacity of the intestine to age and to osteoporosis and the availability of a simplied oral isotopic test of calcium absorption (11) prompted an evaluation of calcium absorp- tion in 59 normal women of various ages and in 16 women with severe osteoporosis. MethodsThe normal population consisted of 59 women with an average age of 40 years (range, 12 to 85 years).This