New Drugs and Novel Targets for Treatment of Invasive Fungal Infections in Patients with Cancer

作者：Christine C. Chiou, Andreas H. Groll, Thomas J. Walsh · 发表于：The Oncologist · 年份：2000 · DOI：10.1634/theoncologist.5-2-120 · 被引用次数：122 · 研究领域：Antifungal resistance and susceptibility、Fungal Infections and Studies、Cancer therapeutics and mechanisms

Invasive fungal infections have emerged as important causes of morbidity and mortality in profoundly immunocompromised patients with cancer. Current treatment strategies for these infections are limited by antifungal resistance, toxicity, drug interactions, and expense. In order to overcome these limitations, new antifungal compounds are being developed, which may improve our therapeutic armamentarium for prevention and treatment of invasive mycoses in high-risk patients with neoplastic diseases.