THE MODE OF ACTION OF VITAMIN D

作者：Anthony W. Norman · 发表于：Biological reviews/Biological reviews of the Cambridge Philosophical Society · 年份：1968 · DOI：10.1111/j.1469-185x.1968.tb01111.x · 被引用次数：118 · 研究领域：Vitamin D Research Studies、Bone health and osteoporosis research、Digestive system and related health

Summary 1. The purpose of this review article is to re‐evaluate and integrate many of the observations related to the physiological effects of vitamin D, using as a working hypothesis the concept that the vitamin may be acting analogously to a steroid hormone in terms of its ability to interact with genetic information and ultimately elicit a physiological response. Prior to this time the problem of the mechanism of action of vitamin D has primarily been approached from the point of view that the vitamin was acting as a cofactor for some specific enzymic reaction. 2. The physiological activities of vitamin D are integrated with those of parathyroid hormone to provide a homeostatic control for the regulation of primarily calcium and secondarily phosphate metabolism. It is proposed that the role of vitamin D in this homeostatic control mechanism is older and more fundamental than that of parathyroid hormone. The interaction of vitamin D on skeletal calcium metabolism may have evolved before the effects of the vitamin on intestinal calcium absorption. 3. There are several physiological defects of calcium metabolism—rickets, osteo‐malacia, vitamin D‐resistant rickets and idiopathic hypercalcaemia—all of which may be a consequence of an aberration in one or another of the interlocking steps of the vitamin D‐dependent and calcium‐dependent homeostatic control mechanism. 4. The most thoroughly established action of vitamin D in vivo is to promote or facilitate the intestinal absorpt...