Alcohol Consumption, Folate Intake, Hepatocellular Carcinoma, and Liver Disease Mortality

作者：E. Christina Persson, Lauren M. Schwartz, Yikyung Park, Britton L. Trabert, Albert R. Hollenbeck, Barry I. Graubard, Neal D. Freedman, Katherine A. McGlynn · 发表于：Cancer Epidemiology Biomarkers & Prevention · 年份：2013 · DOI：10.1158/1055-9965.epi-12-1169 · 被引用次数：82 · 研究领域：Folate and B Vitamins Research、Alcohol Consumption and Health Effects、Alcoholism and Thiamine Deficiency

BACKGROUND: Excessive alcohol consumption is a well-established risk factor for liver disease and hepatocellular carcinoma (HCC). Previous studies have found that increased alcohol consumption can lead to lower absorption of folate. Conversely, higher folate intake has been inversely associated with liver damage and HCC. In the current study, we investigate the effect of alcohol consumption and folate intake on HCC incidence and liver disease mortality in the NIH-American Association of Retired Persons Diet and Health Study. METHODS: The study population included 494,743 participants who reported at baseline their dietary intake for the previous year. Alcohol and folate were analyzed with hazards ratios (HR) and 95% confidence intervals (CI) using multivariate Cox proportional hazards regression models adjusted for age, sex, race, education, smoking, body mass index, and diabetes. HCC incidence (n = 435) was determined through 2006 via linkage with cancer registries, and liver disease mortality (n = 789) was determined through 2008 via linkage to the U.S. Social Security Administration Death Master File and the National Death Index Plus by the National Center for Health Statistics. RESULTS: Consumption of more than three drinks per day was positively associated with both HCC incidence (HR: 1.92; 95%CI: 1.42-2.60) and liver disease mortality (HR: 5.84; 95%CI: 4.81-7.10), whereas folate intake was associated with neither outcome. Folate, however, modified the relationship betwe...