The multiple lifestyle modification for patients with prehypertension and hypertension patients: a systematic review protocol

作者：Juan Li, Hui Zheng, Huai-bin Du, Xiaoping Tian, Yijing Jiang, Shaolan Zhang, Yu Kang, Xiang Li, Jie Chen, Chao Lu, Zhenhong Lai, Fanrong Liang · 发表于：BMJ Open · 年份：2014 · DOI：10.1136/bmjopen-2014-004920 · 被引用次数：23 · 研究领域：Blood Pressure and Hypertension Studies、Sodium Intake and Health、Meta-analysis and systematic reviews

INTRODUCTION: The objective of this systematic review is to investigate the effectiveness, efficacy and safety of multiple concomitant lifestyle modification therapies for patients with hypertension or prehypertension. METHODS AND ANALYSIS: Electronic searches will be performed in the Cochrane Library, OVID, EMBASE, etc, along with manual searches in the reference lists of relevant papers found during electronic search. We will identify eligible randomised controlled trials utilising multiple lifestyle modifications to lower blood pressure. The control could be drug therapy, single lifestyle change or no intervention. Changes in systolic blood pressure and diastolic blood pressure constitute primary end points, and secondary end points include the number of patients meeting the office target blood pressure, the number of patients reporting microvascular or macrovascular complications, etc. We will extract descriptive, methodological and efficacy data from identified randomised controlled trials (RCTs). We will calculate the relative risk for proportion of patients with a normal blood pressure in the experimental group. Dichotomous data will be analysed using risk difference and continuous data using weighted mean differences, both with 95% CI. We will use the χ(2) test and the I(2) statistic to assess heterogeneity. We will use the fixed effects model to compute the efficacy unless there is evidence of heterogeneity. If heterogeneity of effect size persists with respect to bl...