Time-dependent changes of plasma inflammatory biomarkers in type A aortic dissection patients without optimal medical management

作者：Jun Gu, Jia Hu, Hongwei Zhang, Zhenghua Xiao, Zhi Fang, Hong Qian, Minghua Zhong, Yingqiang Guo, Eryong Zhang, Yingkang Shi, Wei Meng · 发表于：Journal of Cardiothoracic Surgery · 年份：2015 · DOI：10.1186/s13019-014-0199-0 · 被引用次数：32 · 研究领域：Aortic Disease and Treatment Approaches、Connective tissue disorders research、Congenital Heart Disease Studies

OBJECTIVES: To investigate the time-dependent changes in plasma levels of interleukin-6, C-reactive protein, and tumor necrosis factor-α in patients with type A aortic dissection (TAAD) who received unoptimal medical management since the onset of dissections. DESIGN AND METHODS: Plasma levels of interleukin-6, C-reactive protein, and tumor necrosis factor-α were detected by ELISA and immuno-turbidimetric assay in 92 TAAD patients at hospital admission. Blood samples from 78 patients with uncontrolled hypertension and 82 healthy volunteers were also analyzed as controls. The occurrence of TAAD-related complication and its relationship with the plasma levels of these inflammatory biomarkers was also investigated. RESULTS: The concentrations of inflammatory mediators were significant higher in TAAD than those in the uncontrolled hypertension and the healthy group. The time to peak plasma level of IL-6.and TNF-α was shorter than that of CRP in TAAD group. In the TAAD group, 51 patients suffered TAAD-related complications, and their plasma level of CRP was significantly higher than that in patients without TAAD-related complications (94.5 ± 58.8 mg/L versus 47.4 ± 47.8 mg/L, p < 0.001). Also, CRP levels strongly correlated with the value of PaO2/FiO2 ratio (r = -0.69, p < 0.001) and creatinine (r = 0.60, p < 0.001). The time to the peak level of CRP was shorter and the duration of persistently high CRP level was longer in the complication group than those in the complication-free ...