Palladium-Catalyzed Coupling of Alkyl Chlorides and Grignard Reagents

作者：Anja C. Frisch, Nadim S. Shaikh, Alexander John Zapf, Matthias Beller · 发表于：Angewandte Chemie International Edition · 年份：2002 · DOI：10.1002/1521-3773(20021104)41:21<4056::aid-anie4056>3.0.co;2-8 · 被引用次数：137 · 研究领域：Catalytic Cross-Coupling Reactions、Catalytic C–H Functionalization Methods、Fluorine in Organic Chemistry

Chloroalkanes refined: A simple catalyst system renders the palladium-catalyzed coupling reaction of functionalized alkyl chlorides and Grignard reagents at room temperature (see example in scheme; PCy3=tricyclohexylphosphane, NMP=N-methylpyrrolidinone).