Chiral Tridentate P,N,N Ligands for Highly Enantioselective Copper‐Catalyzed Propargylic Amination with both Primary and Secondary Amines as Nucleophiles

作者：Cheng Zhang, Yahui Wang, Xin‐Hu Hu, Xin‐Hu Hu, Zhuo Zheng, Jie Xu, Xiang‐Ping Hu, Xiang‐Ping Hu · 发表于：Advanced Synthesis & Catalysis · 年份：2012 · DOI：10.1002/adsc.201200589 · 被引用次数：79 · 研究领域：Asymmetric Hydrogenation and Catalysis、Synthetic Organic Chemistry Methods

Abstract Chiral tridentate P,N,N ligands have been demonstrated to be highly efficient for the copper‐catalyzed enantioselective propargylic amination of propargylic acetates with both primary and secondary amines as nucleophiles, affording the corresponding propargylic amines in high yields and with excellent enantioselectivities (up to 97% ee for secondary amines, and up to 96% ee for primary amines). Furthermore, the present catalytic system was also effective for the more challenging aliphatic propargylic acetate substrates.