Oral cavity and oropharyngeal squamous cell carcinoma—an update

作者：Angela C. Chi, Terry A. Day, Brad W. Neville · 发表于：CA A Cancer Journal for Clinicians · 年份：2015 · DOI：10.3322/caac.21293 · 被引用次数：1103 · 研究领域：Head and Neck Cancer Studies、Oral Health Pathology and Treatment、Salivary Gland Tumors Diagnosis and Treatment

Oral cavity squamous cell carcinoma (OC-SCC) is the most common malignancy of the head and neck (excluding nonmelanoma skin cancer). Recent trends have shown a dramatic rise in the incidence of oropharyngeal squamous cell carcinoma (OP-SCC), with a marked increase in lesions related to human papillomavirus infection. This update presents the latest evidence regarding OC-SCC and OP-SCC. In particular, the authors compare and contrast tumors at these two sites with respect to epidemiology, etiopathogenesis, clinicopathologic presentation, clinical assessment, imaging, management, and prognosis. It is important for clinicians to be aware of differences between OC-SCC and OP-SCC so that appropriate patient education and multidisciplinary care can be provided to optimize outcomes.