Enzyme‐Catalyzed Oxidation of 5‐Hydroxymethylfurfural to Furan‐2,5‐dicarboxylic Acid

作者：Willem P. Dijkman, Daphne Groothuis, Marco W. Fraaije · 发表于：Angewandte Chemie International Edition · 年份：2014 · DOI：10.1002/anie.201402904 · 被引用次数：299 · 研究领域：Catalysis for Biomass Conversion、Polyoxometalates: Synthesis and Applications、Catalysis and Hydrodesulfurization Studies

Furan-2,5-dicarboxylic acid (FDCA) is a biobased platform chemical for the production of polymers. In the past few years, numerous multistep chemical routes have been reported on the synthesis of FDCA by oxidation of 5-hydroxymethylfurfural (HMF). Recently we identified an FAD-dependent enzyme which is active towards HMF and related compounds. This oxidase has the remarkable capability of oxidizing [5-(hydroxymethyl)furan-2-yl]methanol to FDCA, a reaction involving four consecutive oxidations. The oxidase can produce FDCA from HMF with high yield at ambient temperature and pressure. Examination of the underlying mechanism shows that the oxidase acts on alcohol groups only and depends on the hydration of aldehydes for the oxidation reaction required to form FDCA.