Killing of Plasmodium falciparum in vitro by nitric oxide derivatives

作者：Kirk A. Rockett, M M Awburn, William B. Cowden, Ian A. Clark · 发表于：Infection and Immunity · 年份：1991 · DOI：10.1128/iai.59.9.3280-3283.1991 · 被引用次数：307 · 研究领域：Malaria Research and Control、Nitric Oxide and Endothelin Effects、Sulfur Compounds in Biology

We have investigated the in vitro susceptibility of the human malaria parasite Plasmodium falciparum to killing by nitric oxide and related molecules. A saturated solution of nitric oxide did not inhibit parasite growth, but two oxidation products of nitric oxide (nitrite and nitrate ions) were toxic to the parasite in millimolar concentrations. Nitrosothiol derivatives of cysteine and glutathione were found to be about a thousand times more active (50% growth inhibitory concentration, approximately 40 microM) than nitrite.