Emerging microfluidic devices for cell lysis: a review

作者：Lang Nan, Zhuangde Jiang, Xueyong Wei · 发表于：Lab on a Chip · 年份：2013 · DOI：10.1039/c3lc51133b · 被引用次数：159 · 研究领域：Microfluidic and Capillary Electrophoresis Applications、Microfluidic and Bio-sensing Technologies、3D Printing in Biomedical Research

Intracellular components containing information about genetic and disease characteristics are key substances to clinical diagnostics. Cell lysis is therefore a crucial step for efficient extraction and the subsequent analysis of intracellular components. With the advent of advanced manufacturing techniques, a number of micro systems have been proposed and applied for manipulating cells on chips. In this paper, we review emerging microfluidic devices for cell lysis. Different lysis mechanisms and related techniques are compared. The technical details, advantages, and limitations of various microfluidic devices are discussed.