Effects of streptomycin and novobiocin on Staphylococcus aureus gene expression

作者：Kristina Nordström, Martin Ulf Lindberg · 发表于：Journal of Bacteriology · 年份：1978 · DOI：10.1128/jb.133.2.614-620.1978 · 被引用次数：16 · 研究领域：Bacteriophages and microbial interactions、RNA and protein synthesis mechanisms、Genomics and Phylogenetic Studies

Streptomycin and novobiocin induced production of protein A and inhibited production of alpha- and beta-hemolysins in mutants of Staphylococcus aureus strains RN450 and RN1 resistant to these antibiotics. Streptomycin, but not novobiocin, also inhibited propagation of bacteriophages of serological group B, whereas phages of group A were unaffected. Streptomycin had to be present at adsorption of the phage, and 10 mM CACL2 reversed the inhibitory effect. Lysogenization and competence induction occurred in the presence of streptomycin, suggesting that some early phage genes were expressed.