Polyketides from Mantis‐Associated Fungus Daldinia eschscholzii IFB‐TL01

作者：Gang Wang, Jing‐Yang Fan, Wenjing Zhang, Cheng‐Pin Hua, Chao‐Jun Chen, Wei Yan, Hui Ming Ge, Rui‐Hua Jiao, Renxiang Tan · 发表于：Chemistry & Biodiversity · 年份：2015 · DOI：10.1002/cbdv.201400414 · 被引用次数：15 · 研究领域：Microbial Natural Products and Biosynthesis、Fungal Biology and Applications、Plant Pathogens and Fungal Diseases

Three new polyketides, named daldinone F (1), nodulisporin G (2), and dalmanol C (3), together with five known compounds, 4-8, were isolated from cultures of Daldinia eschscholzii. The structures of the new compounds were elucidated by extensive NMR and MS analyses. Compound 1 showed moderate cytotoxic activity against SW480 cancer cells with an IC50 value of 9.59 μM, and its absolute configuration was determined by single crystal X-ray diffraction.