Effects of small concentrations of eicosapentaenoic acid on platelets

作者：Michel Lagarde, Martine Croset, Evelyne Véricel, Catherine Calzada · 发表于：Journal of Internal Medicine · 年份：1989 · DOI：10.1111/j.1365-2796.1989.tb01452.x · 被引用次数：16 · 研究领域：Fatty Acid Research and Health、Eicosanoids and Hypertension Pharmacology、Alcohol Consumption and Health Effects

Increased platelet functions have been associated with enhanced arachidonic acid (AA) metabolism in diabetics and elderly people. We investigated these parameters in both groups after feeding low doses of pure eicosapentaenoic acid (EPA). After such an intake, platelet aggregation induced by various agonists was decreased whereas the oxygenated metabolism of endogenous AA was not substantially altered, and the fatty acid composition of plasma and platelet lipid pools did not change. In the most recent study, the measurement of vitamin E revealed that although its level in plasma was not modified, it was increased in platelets after EPA intake. It is concluded that small amounts of EPA intake do not reduce platelet aggregation in competing with AA metabolism but rather in depressing the peroxide tone of the cell.