Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

作者：Yong Gu, Keisuke Kuida, Hiroko Tsutsui, George Ku, Kathy Hsiao, Mark A Fleming, Nobuki Hayashi, Kazuya Higashino, Haruki Okamura, Kenji Nakanishi, Masashi Kurimoto, Tadao Tanimoto, Richard Anthony Flavell, Vicki L. Sato, Matthew W. Harding, David J. Livingston, Michael S. S. Su · 发表于：Science · 年份：1997 · DOI：10.1126/science.275.5297.206 · 被引用次数：1166 · 研究领域：Immune Response and Inflammation、NF-κB Signaling Pathways、Neutrophil, Myeloperoxidase and Oxidative Mechanisms

The interleukin-1beta (IL-1beta) converting enzyme (ICE) processes the inactive IL-1beta precursor to the proinflammatory cytokine. ICE was also shown to cleave the precursor of interferon-gamma inducing factor (IGIF) at the authentic processing site with high efficiency, thereby activating IGIF and facilitating its export. Lipopolysaccharide-activated ICE-deficient (ICE-/-) Kupffer cells synthesized the IGIF precursor but failed to process it into the active form. Interferon-gamma and IGIF were diminished in the sera of ICE-/- mice exposed to Propionibacterium acnes and lipopolysaccharide. The lack of multiple proinflammatory cytokines in ICE-/- mice may account for their protection from septic shock.