Sleep Duration and Sleep Quality in Relation to 12-Year Cardiovascular Disease Incidence: The MORGEN Study

作者：Marieke P. Hoevenaar‐Blom, Annemieke M. W. Spijkerman, Daan Kromhout, Julia F. van den Berg, W. M. Monique Verschuren · 发表于：SLEEP · 年份：2011 · DOI：10.5665/sleep.1382 · 被引用次数：571 · 研究领域：Sleep and related disorders、Obstructive Sleep Apnea Research、Sleep and Work-Related Fatigue

STUDY OBJECTIVES: We studied sleep duration and sleep quality in relation to cardiovascular disease (CVD) incidence. DESIGN/SETTING: Dutch population-based cohort study. PARTICIPANTS: 20,432 men and women aged 20-65 and with no history of CVD. INTERVENTIONS: N/A. MEASUREMENTS: Sleep duration and sleep quality were assessed by a self-administered questionnaire. Morbidity data, vital status, and causes of death were obtained through linkage with several national registries. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated using Cox proportional hazards models. RESULTS: During 10-15 years of follow-up, 1,486 CVD and 1,148 coronary heart disease (CHD) events occurred. Short sleepers (≤ 6 h) had a 15% higher risk of total CVD (HR: 1.15; 95%CI: 1.00-1.32) and a 23% higher risk of CHD (HR: 1.23 [1.04-1.45]) compared to normal sleepers (7 h) after adjustment for all confounders. Additional adjustment for intermediate biological risk factors attenuated these relative risks to 1.11 (0.97-1.27) for total CVD and to 1.19 (1.00-1.40) for CHD. Short sleepers with poor sleep quality had a 63% higher risk of CVD (HR: 1.63 [1.21-2.19]) and a 79% higher risk of CHD incidence (HR: 1.79 [1.24-2.58]) compared to normal sleepers with good sleep quality, after adjustments for all confounders. We observed no associations between long sleep duration (≥ 9 h) and CVD or CHD incidence. CONCLUSIONS: Short sleepers, especially those with poor sleep quality, have an increased risk...