Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes

作者：Yaw Kai Yan, Michael Melchart, Abraha Habtemariam, Peter John Sadler · 发表于：Chemical Communications · 年份：2005 · DOI：10.1039/b508531b · 被引用次数：759 · 研究领域：Metal complexes synthesis and properties、Ferrocene Chemistry and Applications、Organometallic Compounds Synthesis and Characterization

Our work has shown that certain ruthenium(II) arene complexes exhibit promising anticancer activity in vitro and in vivo. The complexes are stable and water-soluble, and their frameworks provide considerable scope for optimising the design, both in terms of their biological activity and for minimising side-effects by variations in the arene and the other coordinated ligands. Initial studies on amino acids and nucleotides suggest that kinetic and thermodynamic control over a wide spectrum of reactions of Ru(II) arene complexes with biomolecules can be achieved. These Ru(II) arene complexes appear to have an altered profile of biological activity in comparison with metal-based anticancer complexes currently in clinical use or on clinical trial.