Microfluidic high gradient magnetic cell separation

作者：David W. Inglis, Robert E. Riehn, James C. Sturm, Robert H. Austin · 发表于：Journal of Applied Physics · 年份：2006 · DOI：10.1063/1.2165782 · 被引用次数：126 · 研究领域：Microfluidic and Bio-sensing Technologies、Microfluidic and Capillary Electrophoresis Applications、Electrical and Bioimpedance Tomography

Separation of blood cells by native susceptibility and by the selective attachment of magnetic beads has recently been demonstrated on microfluidic devices. We discuss the basic principles of how forces are generated via the magnetic susceptibility of an object and how microfluidics can be combined with micron-scale magnetic field gradients to greatly enhance in principle the fractionating power of magnetic fields. We discuss our efforts and those of others to build practical microfluidic devices for the magnetic separation of blood cells. We also discuss our attempts to integrate magnetic separation with other microfluidic features for developing handheld medical diagnostic tools.