Evidence for the involvement of interleukin 6 in experimental cancer cachexia.

作者：Gideon Strassmann, M Fong, J S Kenney, Chaim O. Jacob · 发表于：Journal of Clinical Investigation · 年份：1992 · DOI：10.1172/jci115767 · 被引用次数：663 · 研究领域：Nutrition and Health in Aging、Vitamin C and Antioxidants Research、Vitamin D Research Studies

In this report we describe an experimental model of cachexia that fulfills the criteria of an early effect with a small tumor mass not related to the growth rate of the tumor, and progressive wasting of muscle and fat without a detectable loss of appetite. C-26.IVX is a cell line derived from murine colon-26 adenocarcinoma which retains the transplantability of the original tumor and induces true cachexia in syngeneic hosts. Evidence is presented to support a role for interleukin (IL-6) as a cachectic factor in the development of cancer cachexia in this model system. Thus, increasing levels of IL-6 in C-26.IVX-bearing mice correlate with the development of cachexia. If the primary tumors were resected, mice gained weight and the levels of IL-6 in the serum were reduced significantly. Moreover, monoclonal antibody to murine IL-6 (but not anti-tumor necrosis factor antibody) was able to significantly suppress the development of key parameters of cachexia in tumor bearing mice.