CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

作者：Florence Susan Wong, Irene Visintin, Wen Li, Richard Anthony Flavell, Charles A. Janeway · 发表于：The Journal of Experimental Medicine · 年份：1996 · DOI：10.1084/jem.183.1.67 · 被引用次数：345 · 研究领域：Diabetes and associated disorders、Pancreatic function and diabetes、Diabetes Management and Research

T cells play an important role in the pathogenesis of diabetes in the nonobese diabetic (NOD) mouse. CD8 cytotoxic T cell lines and clones were generated from the lymphocytic infiltrate in the islets of Langerhans of young (7-wk-old). NOD mice by growing them on (NOD x B6-RIP-B7-1)F1 islets. These cells proliferate specifically to NOD islets and kill NOD islets in vitro. The cells are restricted by H-2Kd, and all bear T cell antigen receptor encoded by V beta 6. When these CD8 T cell lines and clones are adoptively transferred to irradiated female NOD, young NOD-SCID, and CB17-SCID mice, diabetes occurs very rapidly, within 10 d of transfer and without CD4 T cells.