MicroRNAs Associated With HBV Infection And HBV-related HCC

作者：Kunlin Xie, Yange Zhang, Jun Liu, Yong Zeng, Hong Wu · 发表于：Theranostics · 年份：2014 · DOI：10.7150/thno.8715 · 被引用次数：117 · 研究领域：MicroRNA in disease regulation、RNA Interference and Gene Delivery、Circular RNAs in diseases

Hepatitis B virus (HBV) infection is a global problem and a major risk factor for hepatocellular carcinoma (HCC). microRNAs (miRNAs) comprise a group of small noncoding RNAs regulating gene expression at the posttranslational level, thereby participating in fundamental biological processes, including cell proliferation, differentiation, and apoptosis. In this review, we summarize the roles of miRNAs in HBV infection, the recently identified mechanism underlying dysregulation of miRNAs in HBV-associated HCC, and their association with hepatocarcinogenesis. Moreover, we discuss the recent advances in the use of circulating miRNAs in the early diagnosis of HCC as well as therapies based on these aberrantly expressed miRNAs.