Palladium(II)‐Catalyzed CH Activation/CC Cross‐Coupling Reactions: Versatility and Practicality
作者：Xiao Chen, Keary M. Engle, Dong‐Hui Wang, Jin‐Quan Yu · 发表于：Angewandte Chemie International Edition · 年份：2009 · DOI：10.1002/anie.200806273 · 被引用次数：4128 · 研究领域：Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions、Asymmetric Hydrogenation and Catalysis
Abstract Pick your Pd partners : A number of catalytic systems have been developed for palladium‐catalyzed CH activation/CC bond formation. Recent studies concerning the palladium(II)‐catalyzed coupling of CH bonds with organometallic reagents through a Pd II /Pd 0 catalytic cycle are discussed (see scheme), and the versatility and practicality of this new mode of catalysis are presented. Unaddressed questions and the potential for development in the field are also addressed. magnified image In the past decade, palladium‐catalyzed CH activation/CC bond‐forming reactions have emerged as promising new catalytic transformations; however, development in this field is still at an early stage compared to the state of the art in cross‐coupling reactions using aryl and alkyl halides. This Review begins with a brief introduction of four extensively investigated modes of catalysis for forming CC bonds from CH bonds: Pd II /Pd 0 , Pd II /Pd IV , Pd 0 /Pd II /Pd IV , and Pd 0 /Pd II catalysis. A more detailed discussion is then directed towards the recent development of palladium(II)‐catalyzed coupling of CH bonds with organometallic reagents through a Pd II /Pd 0 catalytic cycle. Despite the progress made to date, improving the versatility and practicality of this new reaction remains a tremendous challenge.