Polyol Pathway Activity and Myo-Inositol Metabolism: A Suggested Relationship in the Pathogenesis of Diabetic Neuropathy

作者：David N. Finegold, SARAH A. LATTIMER, Sandra Nolle, Marcy Bernstein, Douglas A. Greene · 发表于：Diabetes · 年份：1983 · DOI：10.2337/diab.32.11.988 · 被引用次数：185 · 研究领域：Aldose Reductase and Taurine、Alcohol Consumption and Health Effects、Biochemical effects in animals

Two major metabolic perturbations, increased polyol (sorbitol) pathway activity and reduced tissue myo-inositol content, are induced in peripheral nerve by hyperglycemia. Although they are commonly invoked as alternative biochemical pathogenetic mechanisms for diabetic neuropathy, their possible interrelationship has never been adequately explored. Therefore, we studied the effect of polyol pathway blockade with sorbinil, a specific inhibitor of aldose reductase, on nerve myo-inositol content in acutely streptozotocin-diabetic rats. Sorbinil administration completely prevented the fall in nerve myo-inositol, thereby implicating increased polyol pathway activity as a likely factor in the fall in nerve myo-inositol content in experimental diabetes.