Listeria monocytogenes meningitis and decreased phagocytosis associated with iron overload.

作者：B. Sweder van Asbeck, H.A. Verbrugh, Bernard A. van Oost, J. J. M. Marx, H W Imhof, J. Verhoef · 发表于：BMJ · 年份：1982 · DOI：10.1136/bmj.284.6315.542 · 被引用次数：105 · 研究领域：Selenium in Biological Systems

A patient with Listeria monocytogenes meningitis was found to have idiopathic haemochromatosis and monocytes with reduced phagocytic capacity. The phagocytic function recovered completely after a series of therapeutic phlebotomies. In-vitro iron had a deleterious effect on the phagocytic capacity of monocytes and granulocytes. These findings show that iron overload in the host can increase susceptibility to L monocytogenes infection not only by increasing the virulence of the organism but also by reducing the phagocytic capacity of the monocytes.