Copper‐Catalyzed Aerobic Decarboxylation/Ketooxygenation of Electron‐Deficient Alkenes

作者：Qingquan Lu, Pan Peng, Yi Luo, Ying Zhao, Minxian Zhou, Aiwen Lei · 发表于：Chemistry - A European Journal · 年份：2015 · DOI：10.1002/chem.201503716 · 被引用次数：23 · 研究领域：Catalytic C–H Functionalization Methods、Oxidative Organic Chemistry Reactions、Synthesis and Catalytic Reactions

A copper-catalyzed ketooxygenation of electron-deficient alkenes was developed. This approach combines O-H alkylation, aerobic decarboxylation, and oxygenation in one transformation. Mechanistic investigation of this reaction showed that the copper salt is responsible for both generating the amidoxyl radical and promoting aerobic decarboxylation.