Solid Cancer Incidence in Atomic Bomb Survivors: 1958–1998

作者：Dale L. Preston, Elaine Ron, Shoji Tokuoka, Sachiyo Funamoto, Nobuo Nishi, Midori Soda, Kiyóhiko Mabuchi, Kazunori Kodama · 发表于：Radiation Research · 年份：2007 · DOI：10.1667/rr0763.1 · 被引用次数：1756 · 研究领域：Radiation Dose and Imaging、Radiation Therapy and Dosimetry、Effects of Radiation Exposure

This is the second general report on radiation effects on the incidence of solid cancers (cancers other than malignancies of the blood or blood-forming organs) among members of the Life Span Study (LSS) cohort of Hiroshima and Nagasaki atomic bomb survivors. The analyses were based on 17,448 first primary cancers (including non-melanoma skin cancer) diagnosed from 1958 through 1998 among 105,427 cohort members with individual dose estimates who were alive and not known to have had cancer prior to 1958. Radiation-associated relative risks and excess rates were considered for all solid cancers as a group, for 19 specific cancer sites or groups of sites, and for five histology groups. Poisson regression methods were used to investigate the magnitude of the radiation-associated risks, the shape of the dose response, how these risks vary with gender, age at exposure, and attained age, and the evidence for inter-site variation in the levels and patterns of the excess risk. For all solid cancers as a group, it was estimated that about 850 (about 11%) of the cases among cohort members with colon doses in excess of 0.005 Gy were associated with atomic bomb radiation exposure. The data were consistent with a linear dose response over the 0- to 2-Gy range, while there was some flattening of the dose response at higher doses. Furthermore, there is a statistically significant dose response when analyses were limited to cohort members with doses of 0.15 Gy or less. The excess risks for all...