Dominant genes for colorectal cancer are not rare

作者：Richard S. Houlston, Andrew R Collins, Julia Elise Slack, Newton E. Morton · 发表于：Annals of Human Genetics · 年份：1992 · DOI：10.1111/j.1469-1809.1992.tb01136.x · 被引用次数：147 · 研究领域：Colorectal Cancer Screening and Detection、Genetic factors in colorectal cancer、Colorectal Cancer Treatments and Studies

The genetic basis for colorectal cancer was investigated by complex segregation analysis of a published series of consecutive pedigrees ascertained through patients undergoing treatment for colorectal cancer. Analysis favoured a dominant gene or genes with a frequency of 0.006 with a lifetime penetrance of 0.63. These genes account for 81% of colorectal cancer in patients under 35, however, by 65 about 85% are phenocopies.