Current Patterns of Presentation and Treatment of Renal Masses: A Clinical Research Office of the Endourological Society Prospective Study

作者：Maria Pilar Laguna, Ferran Algaba, Jeffrey A. Cadeddu, Ralph Victor Clayman, Inderbir Singh Gill, Guillermo Gueglio, Markus Hohenfellner, Adrian Joyce, Jaime Landman, Benjamin J. Lee, Hein van Poppel · 发表于：Journal of Endourology · 年份：2014 · DOI：10.1089/end.2013.0724 · 被引用次数：78 · 研究领域：Renal cell carcinoma treatment、Kidney Stones and Urolithiasis Treatments、Bladder and Urothelial Cancer Treatments

PURPOSE: To assess epidemiologic characteristics, clinical and pathologic patterns of presentation, and treatment strategies in a contemporary population with renal masses (RMs). METHODS: The Clinical Research Office of the Endourological Society collected prospective epidemiologic, clinical, and pathologic data on consecutive patients with RMs who were treated during a 1-year period in 98 centers worldwide. Preoperative assessment and treatment were performed according to local clinical practice guidelines. RESULTS: From January 2010 to February 2012, 4288 patients (4355 cases, 4815 tumors) were treated for a RM. The mean age of the cohort was 61.5 years, and the ratio male:female 1.8:1. Caucasians represented 75% of the population, and the median body mass index was 27. The cohort exhibited a high rate of comorbidity (65.6%), including a 48.5% rate of hypertension; one-third of patients had a combination of two or more comorbidities. One-third of patients (36%) had risk factors for renal-cell carcinoma (RCC), of which smoking and obesity were the most common. Diagnosis was incidental in 67% of cases, and 22.2% of cases had chronic kidney disease stage ≥III at presentation. Median radiologic size was 44 mm (range 2-300 mm) and 68% were cT1. Radical nephrectomy and nephron-sparing surgery (NSS) including ablation were performed in 52% and 46% of cases, respectively, while 3.6% of cases were actively surveyed. Median pathologic size was 43 mm (range 2-300 mm) and 63% of the RC...