PRODUCTION OF TL ANTIBODY BY MICE IMMUNIZED WITH TL- CELL POPULATIONS

作者：Katsutoshi Komuro, Edward A. Boyse, Lloyd J. Old · 发表于：The Journal of Experimental Medicine · 年份：1973 · DOI：10.1084/jem.137.2.533 · 被引用次数：19 · 研究领域：Veterinary medicine and infectious diseases

TL(-) mice make TL antibody when immunized with spleen or bone marrow cells from TL(+) donors, despite the fact that these cells do not express TL antigen. This has been shown to depend on maturation of TL(-) precursors, contained in the inoculum, into TL(+) cells under influence of the recipient's thymus; the differentiated TL(+) cells then evoke production of TL antibody.