Adipose-Derived Stem Cells: Selecting For Translational Success

作者：Kavan S. Johal, Vivien C. Lees, Adam J. Reid · 发表于：Regenerative Medicine · 年份：2015 · DOI：10.2217/rme.14.72 · 被引用次数：55 · 研究领域：Mesenchymal stem cell research、Pluripotent Stem Cells Research、Electrospun Nanofibers in Biomedical Applications

We have witnessed a rapid expansion of in vitro characterization and differentiation of adipose-derived stem cells, with increasing translation to both in vivo models and a breadth of clinical specialties. However, an appreciation of the truly heterogeneous nature of this unique stem cell group has identified a need to more accurately delineate subpopulations by any of a host of methods, to include functional properties or surface marker expression. Cells selected for improved proliferative, differentiative, angiogenic or ischemia-resistant properties are but a few attributes that could prove beneficial for targeted treatments or therapies. Optimizing cell culture conditions to permit re-introduction to patients is critical for clinical translation.