A comparative evaluation of cone beam CT and micro-CT on trabecular bone structures in the human mandible

作者：Jeroen Van Dessel, Y Huang, Melissa Depypere, Izabel Regina Fischer Rubira‐Bullen, Frederik Maes, Reinhilde Jacobs · 发表于：Dentomaxillofacial Radiology · 年份：2013 · DOI：10.1259/dmfr.20130145 · 被引用次数：111 · 研究领域：Dental Radiography and Imaging、Bone health and osteoporosis research、Medical Imaging Techniques and Applications

OBJECTIVES: The main purpose of this study was to determine the accuracy of cone beam CT (CBCT) in measuring the trabecular bone microstructure, in comparison with micro-CT. The subobjective was to examine to what extent bone quality assessment is influenced by X-ray tube current and voltage settings as well as soft tissue surrounding the bone. METHODS: Eight human mandibular bone samples were scanned using three different clinical exposure protocol within water (W1-3) and without water (NW1-3) by a high-resolution (80 µm) CBCT machine (3D Accuitomo 170(®); Morita, Kyoto, Japan). Subsequently, the samples underwent micro-CT scanning (SkyScan 1174®; SkyScan, Antwerp, Belgium). After image acquisition, similar volumes of interest of the trabecular structures captured with CBCT and micro-CT were aligned with each other. Segmentation was then performed, and the morphometric parameters were quantified within the volumes of interest by CTAn software (CTAnalyser(®); SkyScan, Antwerp, Belgium). Descriptive statistical analyses and multiple comparisons between all protocols were applied in R software. RESULTS: High positive Pearson's correlation coefficients were observed between CBCT and micro-CT protocols for all tested morphometric indices except for trabecular thickness. No significant differences were observed between all exposure protocols except for trabecular separation. When examining the soft-tissue effect on trabecular bone structures, no significant differences between NW ...