An Efficient Semi‐Synthetic Method to Construct Docetaxel via Sterically Crowded Linear Side Chain Esterification

作者：Xin Shen, Jidong Yang, Huaxing Zhan, Hu Wang, Shaohong Wu, Zili Chen · 发表于：Chinese Journal of Chemistry · 年份：2013 · DOI：10.1002/cjoc.201201142 · 被引用次数：5 · 研究领域：Cancer Treatment and Pharmacology、Synthetic Organic Chemistry Methods、Chemical Synthesis and Analysis

Abstract An efficient semi‐synthetic method was developed to construct docetaxel 1 by using N , N ‐di‐Boc protected linear isoserine derivative 5 as the side chain source, in which, bulky protecting group on the nitrogen atom blocked C‐2′ position and prohibited unavoidable racemization in previous studies.