Dietary fat, immunological response, and cancer in rats.

作者：Paul M. Newberne · 发表于：PubMed · 年份：1981 · 被引用次数：27 · 研究领域：Cancer, Lipids, and Metabolism、Fatty Acid Research and Health、Cholesterol and Lipid Metabolism

Abstract Immunocompetence can be modified by dietary means. Quality and quantity of fat have been associated with differences in tumor induction and immunological response in animals, and epidemiological observations have indicated that certain dietary lipids are associated in some obscure way with changes in tumor incidence in human populations. Data presented at this Workshop indicate that dietary fats are associated with an enhancement of cancer of the breast, prostate, and colon in human populations and with cancer of the breast and possibly the liver in animal models. Polyunsaturated fats are more enhancing, but cholesterol, other dietary sterols, and their degradation products appear to influence cancer induction either directly or indirectly. Fats appear to be involved in promotion rather than initiation of the carcinogenesis process. That this is not established, however, indicates that an immunological mechanism may be involved in these phenomena. Quality and quantity of dietary fat influence lipid metabolism and sterol synthesis. Obesity depresses immune functions, and further, is involved in some obscure manner with endometrial cancer in women. Lipemia is associated with aberrations of immune function in people; polyunsaturated fats ( a ) decreased rejection crisis in renal transplant patients and ( b ) suppressed delayed hypersensitivity to skin tests in cancer patients and control subjects with evidence for a regulatory role by unsaturated fats on lymphocyte reac...