Neutropenic colitis: A continuing surgical challenge

作者：Nigel M. Williams, A. D. N. Scott · 发表于：British journal of surgery · 年份：1997 · DOI：10.1046/j.1365-2168.1997.02865.x · 被引用次数：46 · 研究领域：Neutropenia and Cancer Infections、Oral health in cancer treatment、Mycobacterium research and diagnosis

BACKGROUND: Neutropenic colitis is a clinicopathological syndrome characteristically seen as a complication of chemotherapy for haematological malignancy. This review explores the pathogenesis of the condition and appraises the options for management. METHODS: A Medline search was carried out and all relevant papers were reviewed. RESULTS: There are many case reports but few published series, so experience is mainly anecdotal. Both medical and surgical management have been successful; it is not possible to compare treatment groups formally. CONCLUSION: The greater use of aggressive multiagent chemotherapy regimens may increase the frequency with which the condition is encountered. Heightened awareness of neutropenic colitis may prompt diagnosis and a better understanding of the pathophysiology may help guide clinical management.