Angiotensin II Type 1 Receptor A/C 1166 Polymorphism

作者：Maurizio Castellano, María Lorenza Muiesan, Marina Beschi, Damiano Rizzoni, Angelo Cinelli, Massimo Salvetti, Gianfranco Pasini, Enzo Porteri, Giorgio Bettoni, Roberto Zulli, Enrico Agabiti‐Rosei · 发表于：Hypertension · 年份：1996 · DOI：10.1161/01.hyp.28.6.1076 · 被引用次数：124 · 研究领域：Renin-Angiotensin System Studies、Hormonal Regulation and Hypertension、Genetic Associations and Epidemiology

The angiotensin II type 1 (AT1) receptor has a key role in mediating the vasoconstrictor and growth-promoting effects of angiotensin II. It has been reported that a polymorphism of the AT1 receptor gene (an A/C transversion at position 1166) may be associated with cardiovascular phenotypes, such as arterial blood pressure and aortic stiffness, that underlie a condition of increased cardiovascular risk. We examined a sample of 212 subjects randomly selected from a general population in northern Italy to investigate the role of AT1 receptor gene polymorphism, in the regulation of blood pressure and cardiovascular growth. We measured blood pressure (both clinic and 24-hour ambulatory recording), left ventricular mass (echocardiography), and carotid artery wall thickness (B-mode ultrasound); we assessed the AT1 receptor genotype by polymerase chain reaction and allele-specific oligonucleotide hybridization. Blood pressure values were lower in CC homozygotes than in heterozygotes and AA homozygotes; the difference was statistically significant for clinic measurements (mean difference for mean blood pressure, -6.6 mm Hg, P = .01; 95% confidence interval, -1.6 to -11.7 mm Hg) but not for ambulatory blood pressure measurements. CC homozygotes also presented a lower incidence of a positive family history of hypertension (P = .027). No statistically significant differences among AT1 receptor A/C1166 genotypes were observed for left ventricular mass or carotid artery wall thickness. We ...