AUGUSTUS: a web server for gene finding in eukaryotes

作者：Mario Stanke, Ralph Steinkamp, Stephan Waack, Burkhard Morgenstern · 发表于：Nucleic Acids Research · 年份：2004 · DOI：10.1093/nar/gkh379 · 被引用次数：1450 · 研究领域：RNA and protein synthesis mechanisms、Genomics and Phylogenetic Studies、Machine Learning in Bioinformatics

We present a www server for AUGUSTUS, a novel software program for ab initio gene prediction in eukaryotic genomic sequences. Our method is based on a generalized Hidden Markov Model with a new method for modeling the intron length distribution. This method allows approximation of the true intron length distribution more accurately than do existing programs. For genomic sequence data from human and Drosophila melanogaster, the accuracy of AUGUSTUS is superior to existing gene-finding approaches. The advantage of our program becomes apparent especially for larger input sequences containing more than one gene. The server is available at http://augustus.gobics.de.