Cutting Edge: Enhancement of Antibody Responses Through Direct Stimulation of B and T Cells by Type I IFN

作者：Agnès Le Bon, Clare Thompson, Elisabeth Kamphuis, Vanessa Durand, Cornelia Rossmann, Ulrich Kalinke, David F. Tough · 发表于：The Journal of Immunology · 年份：2006 · DOI：10.4049/jimmunol.176.4.2074 · 被引用次数：359 · 研究领域：T-cell and B-cell Immunology、Immune Response and Inflammation、Immune Cell Function and Interaction

Type I IFN (IFN-alphabeta) is induced rapidly by infection and plays a key role in innate antiviral defense. IFN-alphabeta also exerts stimulatory effects on the adaptive immune system and has been shown to enhance Ab and T cell responses. We have investigated the importance of B and T cells as direct targets of IFN-alphabeta during IFN-alpha-mediated augmentation of the Ab response against a soluble protein Ag. Strikingly, the ability of IFN-alpha to stimulate the Ab response and induce isotype switching was markedly reduced in mice in which B cells were selectively deficient for the IFN-alphabetaR. Moreover, IFN-alpha-mediated enhancement of the Ab response was also greatly impaired in mice in which T cells were selectively IFN-alphabetaR-deficient. These results indicate that IFN-alphabetaR signaling in both B and T cells plays an important role in the stimulation of Ab responses by IFN-alphabeta.